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VOL. 2, ISSUE 1 (2026)
Therapeutic potential of Vitamin B8 for polyendocrine metabolic ovarian syndrome (PMOS): A novel perspective in endocrinology
Authors
Souvik Tewari, Gargi Chakraborty, Ahana Majumdar, Sinjini Roychoudhury, Shilpa Saha
Abstract
Polyendocrine
Metabolic Ovarian Syndrome (PMOS) has emerged as a broader and metabolically
aggravated form of Polycystic Ovary Syndrome (PCOS), characterized by endocrine
disruption, insulin resistance, chronic inflammation, oxidative stress,
obesity, reproductive dysfunction, and metabolic abnormalities. Increasing
evidence suggests that micronutrient deficiencies and impaired metabolic
signaling play critical roles in the progression of PMOS. Among various
nutritional therapeutics, Vitamin B8, commonly referred to as inositol, has
gained considerable attention due to its insulin-sensitizing, hormonal
balancing, antioxidant, and reproductive health-promoting properties.
Myo-inositol and D-chiro-inositol, the two biologically important isoforms,
participate in intracellular signaling pathways, glucose metabolism, ovarian
follicular maturation, and endocrine regulation. Clinical and experimental
studies demonstrate that Vitamin B8 supplementation improves ovulatory
function, reduces hyperandrogenism, enhances insulin sensitivity, regulates
menstrual irregularities, and decreases metabolic complications associated with
PMOS. Furthermore, Vitamin B8 exhibits anti-inflammatory and antioxidant
actions that may prevent the transition from reproductive dysfunction to
systemic metabolic syndrome. This review explores the pathophysiology of PMOS,
the biochemical significance of Vitamin B8, its molecular mechanisms,
therapeutic efficacy, clinical evidence, and future perspectives in endocrine
and metabolic medicine.
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Pages:11-16
How to cite this article:
Souvik Tewari, Gargi Chakraborty, Ahana Majumdar, Sinjini Roychoudhury, Shilpa Saha "Therapeutic potential of Vitamin B8 for polyendocrine metabolic ovarian syndrome (PMOS): A novel perspective in endocrinology". World Journal of Gynecology, Vol 2, Issue 1, 2026, Pages 11-16
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